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HRID1701122

反应详情

EQUATION

反应方程式

HRID 1701122 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：O=C(Br)CBr
HCID61147

Acetyl bromide, 2-bromo-

C2H2Br2O

结构：Nc1ccc(Cl)cc1C(=O)c1ccc(O)cc1
HCID11402375

Methanone, (2-amino-5-chlorophenyl)(4-hydroxyphenyl)-

C13H10ClNO2

PRODUCTS

生成物

1
结构：O=C(CBr)Nc1ccc(Cl)cc1C(=O)c1ccc(O)cc1
HCID12517306

2-Bromo-N-[4-chloro-2-(4-hydroxybenzoyl)phenyl]acetamide

C15H11BrClNO3

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O
溶剂HCID962

Water

H2O

结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

A solution of 41 g (0.165 mole) 2-amino-5-chloro-4'-hydroxybenzophenone in 800 ml of ether and 200 ml of water was cooled to 5°. The mixture was stirred while 20 ml (0.277 mole) of bromoacetyl bromide and a 20% solution of sodium carbonate were added alternately keeping the solution slightly basic. After 20 min. the reaction mixture was filtered to collect 60 g (about 100%) of product mp 201°-202°. Recrystallization from ethanol gave colorless prisms, mp 201°-203°.

WORKUP

后处理

  1. filtrationAfter 20 min. the reaction mixture was filtered
  2. customto collect 60 g (about 100%) of product mp 201°-202°
  3. customRecrystallization from ethanol
  4. customgave colorless prisms, mp 201°-203°