Acetone → HCID 54365370, compound

HRID 1701139Notes

Reaction equation

HRID 1701139 reaction equation
[OH-:1].[Na+].[F:3][C:4]([F:17])([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1)[CH:5]([F:7])[F:6].[CH3:18][C:19]([CH3:21])=[O:20]>O>[F:3][C:4]([F:17])([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[CH:16][C:9](=[O:1])[CH:10]=[CH:11][C:12]2[CH:15]=[CH:21][C:19]([O:20][C:4]([F:3])([F:17])[CH:5]([F:6])[F:7])=[CH:18][CH:13]=2)=[CH:11][CH:10]=1)[CH:5]([F:7])[F:6]

Participants

5

Reactant 3

HCID 180AcetoneHCID 14798Sodium HydroxideHCID 1188044-(1,1,2,2-Tetrafluoroethoxy)-benzaldehyde

Product 1

HCID 54365370HCID 54365370, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Aqueous sodium hydroxide (28.1 ml; 10%) is added dropwise, rapidly, to a stirred mixture of p-(1,1,2,2-tetrafluoroethoxy)benzaldehyde (11 ml; 0.069 mole), acetone (2.4 ml; 0.33 mole), absolute alcohol (135 ml) and water (14 ml). The reaction mixture exotherms to 30° C. The reaction mixture is then cooled, the precipitated material is filtered, washed and dried to afford 3.8 g (25%) of title product.

Workup

  1. customexotherms to 30° C
  2. temperatureThe reaction mixture is then cooled
  3. filtrationthe precipitated material is filtered
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-a432fde5fe9e438a97bcad727bc54545
Source dataset
uspto-grants-1980_03
Patent number
US04191768

Reaction notes

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