Acetone → HCID 54244609, compound

HRID 1701142Notes

Reaction equation

HRID 1701142 reaction equation
[F:1][CH:2]([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1.[CH3:13][C:14]([CH3:16])=[O:15].[CH2:17]([OH:19])[CH3:18].[OH-].[Na+]>O>[F:1][CH:2]([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[CH:18][C:17](=[O:19])[CH:5]=[CH:6][C:7]2[CH:10]=[CH:16][C:14]([O:15][CH:2]([F:12])[F:1])=[CH:13][CH:8]=2)=[CH:6][CH:5]=1

Participants

6

Reactant 4

HCID 180AcetoneHCID 702EthanolHCID 14798Sodium HydroxideHCID 2736986p-(Difluoromethoxy)benzaldehyde

Product 1

HCID 54244609HCID 54244609, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of p-difluoromethoxybenzaldehyde (10.7 g; 0.0622 mole), acetone (2.2 ml; 0.0296 mole, ethanol (103 ml) and water (10 ml) is added dropwise, rapidly, and with stirring to an aqueous sodium hydroxide solution (25.5 ml; 10%). The reaction mixture exotherms to 30° C. and a precipitate forms. The precipitate is filtered, washed and dried to afford 9.0 g (97.2%) of title product.

Workup

  1. customexotherms to 30° C.
  2. filtrationThe precipitate is filtered
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-6b25301155324f29914c01d95e0b02b1
Source dataset
uspto-grants-1980_03
Patent number
US04191768

Reaction notes

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