反应详情

温度

50 °C

32.6 grams of maleic anhydride were dissolved in 600 ml of toluene and there were dropped into this solution under stirring a 50° C. warm solution of 50.0 grams of (+)-norephedrine in 100 ml of toluene. Then stirring was continued for 30 more minutes at this temperature. The product was allowed to cool, filtered off with suction, dried and recrystallized from ethyl acetate. Yield: 63.5 grams=77.0% of theory. M.P. 154°-156°

1. additionthere were dropped into this solution
2. stirringThen stirring
3. temperatureto cool
4. filtrationfiltered off with suction
5. customdried
6. customrecrystallized from ethyl acetate