Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Maleic Anhydride | HCID 7923 | — |
| Reactant | (1S,2R)-2-amino-1-phenylpropan-1-ol | HCID 26934 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 70055034 | HCID 70055034 | — |
Reaction Steps
32.6 grams of maleic anhydride were dissolved in 600 ml of toluene and there were dropped into this solution under stirring a 50° C. warm solution of 50.0 grams of (+)-norephedrine in 100 ml of toluene. Then stirring was continued for 30 more minutes at this temperature. The product was allowed to cool, filtered off with suction, dried and recrystallized from ethyl acetate. Yield: 63.5 grams=77.0% of theory. M.P. 154°-156°
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04191777 |
|---|
| Source dataset | uspto-grants-1980_03 |
|---|
| ORD ID | ord-9c4b933bfb0c47b18a121e01529eec36 |
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| Source note | uspto-grants-1980_03 |
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