Methyl chloroformate → HCID 53703941, compound

HRID 1701162Notes

Reaction equation

HRID 1701162 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([S:16]([CH2:18][C:19]([OH:21])=[O:20])=[O:17])[CH3:15])=[CH:10][CH:9]=1.[CH2:22](N(CC)CC)C.COC(Cl)=O>C(Cl)(Cl)Cl>[CH3:22][O:20][C:19](=[O:21])[CH2:18][S:16]([CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])=[CH:9][CH:10]=1)[CH3:15])=[O:17]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 20348737HCID 20348737, compound

Product 1

HCID 53703941HCID 53703941, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

306 mgm (1 millimol) of [1-(2'-fluoro-4-biphenylyl)-ethylsulfinyl]-acetic acid and 0.15 ml of triethylamine were dissolved in 2 ml of chloroform, and 0.15 ml of chloroformic acid methyl ester was added to the solution at room temperature. After 30 minutes of standing, the mixture was washed with water, dried and evaporated, and the residue was recrystallized from 1 ml of isopropanol. Yield: 200 mgm (62.5% of theory); m.p. 75°-78° C.

Workup

  1. washthe mixture was washed with water
  2. customdried
  3. customevaporated
  4. customthe residue was recrystallized from 1 ml of isopropanol

Sources & evidence

ORD record
ord-6836e4e38bf64baeba5595ddb79b3f5e
Source dataset
uspto-grants-1980_03
Patent number
US04191776

Reaction notes

Loading…