HCID 12595981, compound → HCID 13290818, compound

HRID 1701289Notes

Reaction equation

HRID 1701289 reaction equation
[NH2:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][N:5]1[CH:9]=[CH:8][CH:7]=[C:6]1C(O)=O.CN1CCN(C2C3=CC=CN3CC3C=CC=CC=3N=2)CC1>C(Cl)Cl>[NH2:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][N:5]1[CH:9]=[CH:8][CH:7]=[CH:6]1

Participants

4

Reactant 2

HCID 12595981HCID 12595981, compoundHCID 12617933HCID 12617933, compound2×

Product 1

HCID 13290818HCID 13290818, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(o-Aminobenzyl)-2-pyrrolecarboxylic acid, prepared by hydrolysis of 1-(o-aminobenzyl)-2-pyrrolecarbonitrile (Example 1) with potassium hydroxide (Example 1), is heated above its melting point for several minutes (245°-250° C.). After the evolution of gases ceases the residue is cooled, taken up in methylene chloride, and a small amount of precipitate is filtered. The filtrate is evaporated and the residue is crystallized with the aid of petroleum ether to give 1-(o-aminobenzyl)pyrrole.

Workup

  1. temperatureis heated above its
  2. customfor several minutes
  3. custom(245°-250° C.)
  4. temperatureis cooled
  5. filtrationa small amount of precipitate is filtered
  6. customThe filtrate is evaporated
  7. customthe residue is crystallized with the aid of petroleum ether

Sources & evidence

ORD record
ord-5f16212a64504e278690938a98449316
Source dataset
uspto-grants-1980_03
Patent number
US04192803

Reaction notes

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