HCID 12595981, compound → HCID 13290818, compound

Participants

Reaction Steps

1-(o-Aminobenzyl)-2-pyrrolecarboxylic acid, prepared by hydrolysis of 1-(o-aminobenzyl)-2-pyrrolecarbonitrile (Example 1) with potassium hydroxide (Example 1), is heated above its melting point for several minutes (245°-250° C.). After the evolution of gases ceases the residue is cooled, taken up in methylene chloride, and a small amount of precipitate is filtered. The filtrate is evaporated and the residue is crystallized with the aid of petroleum ether to give 1-(o-aminobenzyl)pyrrole.

Provenance & Evidence