Acetic Anhydride → N-(2,3-Dihydro-1H-inden-2-yl)acetamide

HRID 1701343Notes

Reaction equation

HRID 1701343 reaction equation
Cl.[CH2:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]1[NH2:11].O.O.O.[C:15]([O-])(=[O:17])[CH3:16].[Na+].C(OC(=O)C)(=O)C>>[C:15]([NH:11][CH:3]1[CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:2]1)(=[O:17])[CH3:16]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 1227642-Aminoindan hydrochlorideHCID 23665404Sodium Acetate Trihydrate

Product 1

HCID 12452137N-(2,3-Dihydro-1H-inden-2-yl)acetamide

Procedure

25 g. of 2-indanamine hydrochloride (0.15 mole), 20 g. of sodium acetate trihydrate (0.14 mole), and 40 g. of acetic anhydride (0.4 mole) were stirred at 25° C. for sixteen hours. The mixture was evaporated and the residue was partitioned between chloroform and water. The chloroform extracts were pooled, washed with 10% hydrochloric acid and then with 5% aqueous sodium carbonate, dried and evaporated to yield N-acetyl-2-indanamine.

Workup

  1. customThe mixture was evaporated
  2. customthe residue was partitioned between chloroform and water
  3. washwashed with 10% hydrochloric acid
  4. dry with materialwith 5% aqueous sodium carbonate, dried
  5. customevaporated

Sources & evidence

ORD record
ord-d86580684e1241d2bd4b0cb4777a8409
Source dataset
uspto-grants-1980_03
Patent number
US04192888

Reaction notes

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