Acetic Anhydride → N-(2,3-Dihydro-1H-inden-2-yl)acetamide

Participants

Reaction Steps

25 g. of 2-indanamine hydrochloride (0.15 mole), 20 g. of sodium acetate trihydrate (0.14 mole), and 40 g. of acetic anhydride (0.4 mole) were stirred at 25° C. for sixteen hours. The mixture was evaporated and the residue was partitioned between chloroform and water. The chloroform extracts were pooled, washed with 10% hydrochloric acid and then with 5% aqueous sodium carbonate, dried and evaporated to yield N-acetyl-2-indanamine.

Provenance & Evidence