反应详情

A solution of 17 g of 3-bromomethyl-4'-chlorobenzophenone in 75 cc of dioxane at 70° C. was added to the solution of 26.5 g of potassium cyanide in 75 cc of water and the mixture was refluxed with stirring for 6 hours. After cooling, 500 cc of ether were added to the mixture and the aqueous phase was decanted off. The organic phase was washed with water until the wash waters were neutral, dried over magnesium sulfate, treated with activated carbon, filtered and evaporated to dryness under reduced pressure. The residue was crystallized from methanol to obtain 9.61 g of 3-p-chlorobenzoyl phenyl acetonitrile melting at 86° to 90° C.

1. temperaturethe mixture was refluxed
2. temperatureAfter cooling
3. customthe aqueous phase was decanted off
4. washThe organic phase was washed with water until the wash waters
5. dry with materialdried over magnesium sulfate
6. additiontreated with activated carbon
7. filtrationfiltered
8. customevaporated to dryness under reduced pressure
9. customThe residue was crystallized from methanol