HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-methylpyridine → Ethyl 2-cyano-3-(5-methyl-2-pyridylamino)acrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-methylpyridine | HCID 15348 | — |
| Reactant | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| Product | Ethyl 2-cyano-3-(5-methyl-2-pyridylamino)acrylate | HCID 4480416 | 50.5% |
Reaction Steps
A mixture of 2-amino-5-methylpyridine (5.0 g., 46.2 mmoles) and ethyl ethoxymethylenecyanoacetate (7.82 g., 46.2 mmoles) was heated by means of an oil bath maintained at 100° for 15 minutes. The mixture was cooled and the resultant solid recrystallized from acetonitrile to give the title compound (5.4 g., 50.5%), m.p. 170°-171.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04192944 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-2459600189f240dbaeb4338248f38bef |
| Source note | uspto-grants-1980_03 |