反应详情

A mixture of 2-amino-5-methylpyridine (5.0 g., 46.2 mmoles) and ethyl ethoxymethylenecyanoacetate (7.82 g., 46.2 mmoles) was heated by means of an oil bath maintained at 100° for 15 minutes. The mixture was cooled and the resultant solid recrystallized from acetonitrile to give the title compound (5.4 g., 50.5%), m.p. 170°-171.5°.

1. temperaturewas heated by means of an oil bath
2. temperaturemaintained at 100° for 15 minutes
3. temperatureThe mixture was cooled
4. customthe resultant solid recrystallized from acetonitrile