反应详情

A solution of 2-amino-5-n-butylpyridine (3.72 g., 23.43 mmoles) and ethyl ethoxymethylenecyanoacetate (3.96 g., 23.43 mmoles) in toluene was heated for 10 minutes by means of an oil bath maintained at 100°. The solution was cooled and treated with Skellysolve B (200 ml.). The mixture was triturated for 18 hours at room temperature and then filtered. The collected title compound (4.3 g., 67.2%) had m.p. 69°-73°.

1. temperaturemaintained at 100°
2. temperatureThe solution was cooled
3. customThe mixture was triturated for 18 hours at room temperature
4. filtrationfiltered
5. customThe collected title compound (4.3 g., 67.2%)