HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 11beta-Dipropylaminoacetoxy-3alpha-hydroxy-5alpha-pregnan-20-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 20,20-Ethylenedioxy-11beta-dipropylaminoacetoxy-5alpha-pregnan-3alpha-ol | HCID 70583543 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 11beta-Dipropylaminoacetoxy-3alpha-hydroxy-5alpha-pregnan-20-one | HCID 22810323 | — |
Reaction Steps
Toluene-4-sulphonic acid (120 mg) was added to a solution of 20,20-ethylenedioxy-11β-dipropylaminoacetoxy-5α-pregnan-3α-ol (260 mg) in acetone (20 ml). The mixture was kept at room temperature until reaction was judged complete (TLC), when sodium bicarbonate solution was added and the precipitated material collected by filtration. Crystallization from ether-petroleum ether afforded title compound, m.p. 120°-122°, [α]D +92°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04192871 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-c67082fb4a05434f809a275d840f4ae7 |
| Source note | uspto-grants-1980_03 |