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HRID1701431

反应详情

EQUATION

反应方程式

HRID 1701431 的结构方程式

REACTANTS

反应物

3
结构：Cc1ccc(S(=O)(=O)O)cc1
HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：CCCN(CCC)CC(=O)O[C@H]1C[C@]2(C)[C@@H](C3(C)OCCO3)CC[C@H]2[C@@H]2CC[C@H]3C[C@H](O)CC[C@]3(C)[C@H]21
HCID70583543

未命名化合物

PRODUCTS

生成物

1
结构：CCCN(CCC)CC(=O)O[C@H]1C[C@]2(C)[C@@H](C(C)=O)CC[C@H]2[C@@H]2CC[C@H]3C[C@H](O)CC[C@]3(C)[C@H]21
HCID22810323

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Toluene-4-sulphonic acid (120 mg) was added to a solution of 20,20-ethylenedioxy-11β-dipropylaminoacetoxy-5α-pregnan-3α-ol (260 mg) in acetone (20 ml). The mixture was kept at room temperature until reaction was judged complete (TLC), when sodium bicarbonate solution was added and the precipitated material collected by filtration. Crystallization from ether-petroleum ether afforded title compound, m.p. 120°-122°, [α]D +92°.

WORKUP

后处理

  1. customThe mixture was kept at room temperature until reaction
  2. additionwas added
  3. filtrationthe precipitated material collected by filtration
  4. customCrystallization from ether-petroleum ether