Diethylamine → HCID 70584227, compound

HRID 1701434Notes

Reaction equation

[OH:1][C@@H:2]1[CH2:21][CH2:20][C@@:19]2([CH3:22])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:18]2[C@@H:17]([O:23][C:24](=[O:27])[CH2:25]I)[CH2:16][C@@:15]2([CH3:28])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1.[CH2:29]([NH:31][CH2:32][CH3:33])[CH3:30]>>[CH2:29]([N:31]([CH2:25][C:24]([O:23][C@H:17]1[CH2:16][C@@:15]2([CH3:28])[C@@H:8]([CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[C@H:7]2[C@H:18]1[C@:19]1([CH3:22])[C@@H:4]([CH2:5][CH2:6]2)[CH2:3][C@H:2]([OH:1])[CH2:21][CH2:20]1)=[O:27])[CH2:32][CH3:33])[CH3:30]

Participants

Reactant 2

HCID 8021Diethylamine

HCID 86736867HCID 86736867, compound

Product 1

HCID 70584227HCID 70584227, compound

Procedure

3α-Hydroxy-11β-iodoacetoxy-5α-pregnan-20-one (50 mg) in the appropriate solvent (see Table 4) was treated with diethylamine (0.2 ml) and the resulting mixture was kept at room temperature.

Workup

customwas kept at room temperature

Sources & evidence

ORD record: ord-4eda4f37962542809480cf3e32380a7c
Source dataset: uspto-grants-1980_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04192871

Reaction notes

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