Pyridine → HCID 70583396, compound

HRID 1701449Notes

Reaction equation

HRID 1701449 reaction equation
[C:1]([C@H:3]1[CH2:8][CH2:7][C@H:6]2[C@H:9]3[C@H:19]([C@@H:20]([OH:22])[CH2:21][C@:4]12[CH3:5])[C@:17]1([CH3:18])[C@H:12]([CH2:13][C@H:14]([OH:23])[CH2:15][CH2:16]1)[CH2:11][CH2:10]3)#[N:2].N1C=CC=CC=1.[C:30](OC(=O)C)(=[O:32])[CH3:31]>Cl>[C:30]([O:23][C@@H:14]1[CH2:15][CH2:16][C@@:17]2([CH3:18])[C@@H:12]([CH2:11][CH2:10][C@@H:9]3[C@@H:19]2[C@@H:20]([OH:22])[CH2:21][C@@:4]2([CH3:5])[C@H:6]3[CH2:7][CH2:8][C@@H:3]2[C:1]#[N:2])[CH2:13]1)(=[O:32])[CH3:31]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 70583923HCID 70583923, compound

Product 1

HCID 70583396HCID 70583396, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 17β-cyano-5α-androstane-3α,11β-diol (20 mg) in acetic anhydride (0.5 ml) containing pyridine (0.5 ml) was kept at room temperature for three days. The mixture was diluted with 2N-hydrochloric acid and extracted with ethyl acetate. Evaporation of the organic extract afforded title compound (21 mg).

Workup

  1. extractionextracted with ethyl acetate
  2. customEvaporation of the
  3. extractionorganic extract

Sources & evidence

ORD record
ord-a89717dfccaa469a95e81ac505f8a385
Source dataset
uspto-grants-1980_03
Patent number
US04192871

Reaction notes

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