反应详情

To a solution of 257 mg. (2 mmol) of 2-chloro-4-aminopyridine dissolved in ten ml. of dry acetone, 238 mg. (2 mmol) of phenyl isocyanate is added and the mixture is stirred at room temperature for 8 hrs. The solvent is evaporated under a reduced pressure, the residue is chromatographed over alumina, and the column is developed with chloroform. Eluates containing the objective substance are collected, and the solvent is evaporated under a reduced pressure. The residue is recrystallized from acetone-ether mixture and 364 mg. of N-(2-chloro-4-pyridyl)-N'-phenylurea is obtained. Yield, 73.5%, mp 173°-174° C.

1. customThe solvent is evaporated under a reduced pressure
2. customthe residue is chromatographed over alumina
3. additionEluates containing the objective substance
4. customare collected
5. customthe solvent is evaporated under a reduced pressure
6. customThe residue is recrystallized from acetone-ether mixture and 364 mg