Sodium Bicarbonate → Propyl N-((5-methyl-2-(isopropyl)cyclohexyl)carbonyl)glycinate

HRID 1701500Notes

Reaction equation

HRID 1701500 reaction equation
[CH:1]1([CH3:13])[CH2:6][CH2:5][CH:4]([CH:7]([CH3:9])[CH3:8])[CH:3]([C:10](Cl)=[O:11])[CH2:2]1.Cl.[CH2:15]([O:18][C:19](=[O:22])[CH2:20][NH2:21])[CH2:16][CH3:17].C(=O)(O)[O-].[Na+]>>[CH2:15]([O:18][C:19](=[O:22])[CH2:20][NH:21][C:10]([CH:3]1[CH:4]([CH:7]([CH3:9])[CH3:8])[CH2:5][CH2:6][CH:1]([CH3:13])[CH2:2]1)=[O:11])[CH2:16][CH3:17]

Participants

4

Reactant 3

HCID 516892Sodium BicarbonateHCID 2759254Propyl aminoacetate hydrochlorideHCID 13734319Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-

Product 1

HCID 56843152Propyl N-((5-methyl-2-(isopropyl)cyclohexyl)carbonyl)glycinate

Procedure

Following the procedure of Example 2 p-menth-3-oyl chloride (2.0 g., 0.01 moles), was reacted with glycine propyl ester hydrochloride (1.5 g., 0.01 moles) and sodium bicarbonate (1.6 g., 0.02 moles). The crude product was distilled b.p. 170°/0.1 mm. (After distillation the product rapidly solidifies). (Found, C: 68.2; H: 1016; N: 5.0. C16H29NO3 requires, C: 67.8; H: 10.6; N: 4.9.)

Workup

  1. distillationThe crude product was distilled b.p. 170°/0.1 mm
  2. distillation(After distillation the product

Sources & evidence

ORD record
ord-a702d124be6645c29041a87f61c34ef9
Source dataset
uspto-grants-1980_03
Patent number
US04193936

Reaction notes

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