反应详情

4-Methoxy-naphthoic acid chloride (35 g; prepared by action of phosphorous pentachloride on the acid of m.p. 250° C.) followed by methyl 1-methyl-pyrrole-2-carboxylate (22 g) are dissolved in 1,2-dichloroethane (400 ml). To the stirred solution, at about -20° C., is slowly added anhydrous aluminium chloride (23 g). After one hour, the resulting material is poured over 1 kg crushed ice. The organic phase is decanted off and the aqueous phase is extracted with chloroform (500 ml). The organic solution is then dried and the solvents are evaporated off. The solid residue (28 g) is washed with isopropyl ether (200 ml), to give methyl 1-methyl-4-(4-methoxy-1-naphthoyl)-pyrrole-2-carboxylate, m.p.=162° C., in a yield of 50%.

1. customat about -20° C.
2. additionthe resulting material is poured over 1 kg
3. customcrushed ice
4. customThe organic phase is decanted off
5. extractionthe aqueous phase is extracted with chloroform (500 ml)
6. customThe organic solution is then dried
7. customthe solvents are evaporated off
8. washThe solid residue (28 g) is washed with isopropyl ether (200 ml)