Phosphorus oxychloride → HCID 20528942, compound

HRID 1701551Notes

Reaction equation

O[C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][C:5]([NH2:14])=[CH:4][N:3]=1.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][C:5]([NH2:14])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178508040HCID 178508040, compound

Product 1

HCID 20528942HCID 20528942, compound

Procedure

Treatment of the 2-hydroxy-3-morpholino-5-aminopyrazine with phosphorus oxychloride by the method described in Preparation 13, Step B, gives the desired 2-chloro-3-morpholino-5-aminopyrazine.

Sources & evidence

ORD record: ord-e3acb20d04f34311879da96c843e634b
Source dataset: uspto-grants-1980_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04193995

Reaction notes

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