Hydrochloric Acid → HCID 20346977, compound

HRID 1701569Notes

Reaction equation

HRID 1701569 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:8]([C:10]1[CH:15]=[C:14]([CH2:16][CH3:17])[CH:13]=[C:12]([CH2:18][CH3:19])[C:11]=1[N:20]=[C:21]=[S:22])[CH3:9].Cl>>[CH2:8]([C:10]1[CH:15]=[C:14]([CH2:16][CH3:17])[CH:13]=[C:12]([CH2:18][CH3:19])[C:11]=1[NH:20][C:21]([NH:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)=[S:22])[CH3:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 7965CyclohexylamineHCID 20347131HCID 20347131, compound

Product 1

HCID 20346977HCID 20346977, compound

Procedure

20.0 g of cyclohexylamine are taken and 15.0 g of 2,4,6-triethyl-phenyl isothiocyanate are introduced whilst stirring. The reaction takes place with slight evolution of heat. The mixture is left to stand for 12 hours and is then stirred with dilute hydrochloric acid and filtered. The crystalline reaction product is triturated with dilute methanol filtered off, washed and dried; yield 22.0 g; melting point 97°-99° C. The elementary analysis and NMR- and IR-spectrum agree with the assumed structure.

Workup

  1. temperatureof heat
  2. waitThe mixture is left
  3. filtrationfiltered
  4. customThe crystalline reaction product is triturated with dilute methanol
  5. filtrationfiltered off
  6. washwashed
  7. customdried

Sources & evidence

ORD record
ord-bb98286e8d99498fb8ceafebc9e8f511
Source dataset
uspto-grants-1980_03
Patent number
US04194008

Reaction notes

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