反应详情

To a solution of 50 mg of benzhydryl 2-(3-phenoxyacetamido-2-oxoazetidin-1-yl)-3-methyl-3-butenoate in 10 ml of methylene chloride was added 3 drops of triethylamine. After 2 hours at room temperature the reaction mixture was washed thoroughly with brine and dilute acid. After drying, the solution was evaporated in vacuo to dryness to provide 50 mg of the title product: nmr (CDCl3) δ 2.05 (s, 3, CH3), 2.25 (s, 3, CH3), 3.60 (2, m, azetidinone C4 --H), 5.02 (m, 1, C3 --H), 4.55 (s, 2, --OCH2CO--), and 7.2 (b, 15, ArH).

1. washAfter 2 hours at room temperature the reaction mixture was washed thoroughly with brine
2. additiondilute acid
3. customAfter drying
4. customthe solution was evaporated in vacuo to dryness