Toluene → 5-Fluoropyridine-3-carbaldehyde

HRID 170176Notes

Reaction equation

HRID 170176 reaction equation
[CH3:13][CH:14]([CH2:15][AlH:16][CH2:17][CH:18]([CH3:19])[CH3:20])[CH3:21].[CH3:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[F:1][c:2]1[cH:3][n:4][cH:5][c:6]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[cH:12]1>>[F:1][c:2]1[cH:3][n:4][cH:5][c:6]([CH:7]=[O:8])[cH:12]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 14487Diisobutylaluminum hydrideHCID 211184Ethyl 5-fluoronicotinate

Product 1

HCID 141411595-Fluoropyridine-3-carbaldehyde

Sources & evidence

ORD record
ord-26a41bc753ef413ab38ba5bc4a4d50eb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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