2-Fluorobenzoic acid → 2-Fluorobenzoyl chloride

HRID 1701803Notes

Reaction equation

HRID 1701803 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:13])=O>C1C=CC=CC=1>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:13])=[O:5]

Participants

4

Reactant 2

HCID 99352-Fluorobenzoic acidHCID 24386Thionyl Chloride

Product 1

HCID 98082-Fluorobenzoyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 14.0 g (0.1 mole) of 2-fluorobenzoic acid and 30 ml of thionyl chloride (SOCl2) is refluxed in 70 ml of benzene for four hours. The mixture is cooled and concentrated under vacuum to give 2-fluorobenzoyl chloride as a liquid.

Workup

  1. temperatureThe mixture is cooled
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-2f2fd7cdc15b4ed6bd2ac0e8ccccc61c
Source dataset
uspto-grants-1980_03
Patent number
US04195023

Reaction notes

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