Phosgene → HCID 15583064, compound

HRID 1701808Notes

Reaction equation

HRID 1701808 reaction equation
[CH:1]1([O:7][CH2:8][CH2:9][O:10][C:11]2[CH:12]=[C:13]([CH:15]=[CH:16][CH:17]=2)[NH2:14])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:18](Cl)(Cl)=[O:19]>C1(C)C=CC=CC=1>[CH:1]1([O:7][CH2:8][CH2:9][O:10][C:11]2[CH:12]=[C:13]([N:14]=[C:18]=[O:19])[CH:15]=[CH:16][CH:17]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 15583071HCID 15583071, compound

Product 1

HCID 15583064HCID 15583064, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 14.5 g of 3-[2-(cyclohexyloxy)-ethoxy]aniline in 100 ml of toluene was added dropwise to 100 ml of toluene containing 12 g of phosgene. The resultant mixture was refluxed for 1 hour and concentrated under reduced pressure. The concentrate was purified by high vacuum distillation to give 14 g of 3-[2-(cyclohexyloxy)-ethoxy]phenyl isocyanate. B.P., 112°-115° C./0.06 mmHg. nD23 1.5283.

Workup

  1. concentrationconcentrated under reduced pressure
  2. distillationThe concentrate was purified by high vacuum distillation

Sources & evidence

ORD record
ord-3f3b620245124fe7a4b796df57d77ec3
Source dataset
uspto-grants-1983_04
Patent number
US04378992

Reaction notes

Loading…