2-Amino-5-Nitrothiazole → HCID 3422255, compound

HRID 1701834Notes

Reaction equation

HRID 1701834 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[NH2:11][C:12]1[S:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=1>N1C=CC=CC=1>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:11][C:12]1[S:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=1)=[O:5]

Participants

4

Reactant 2

HCID 84862-Amino-5-NitrothiazoleHCID 691102-Chlorobenzoyl chloride

Product 1

HCID 3422255HCID 3422255, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

By following the procedure of the first part of Example 1, but using 2-chlorobenzoyl chloride (26.3 g), 2-amino-5-nitrothiazole (21.8 g) and pyridine (ca 150 ml), there was obtained 2-chloro-N-(5-nitro-2-thiazolyl)benzamide, m.pt 221°-222°, after recrystallisation from acetic acid.

Sources & evidence

ORD record
ord-d82ecbc0ea774d5eaefeeb78a6be646b
Source dataset
uspto-grants-1983_04
Patent number
US04379156

Reaction notes

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