Thionyl Chloride → HCID 13207837, compound

HRID 1701849Notes

Reaction equation

HRID 1701849 reaction equation
S(Cl)([Cl:3])=O.[ClH:5].Cl.[CH3:7][C@H:8]1[NH:13][C@@H:12]([CH3:14])[CH2:11][N:10]([CH2:15][CH2:16][CH2:17]O)[CH2:9]1>>[ClH:3].[ClH:5].[CH3:7][C@H:8]1[NH:13][C@@H:12]([CH3:14])[CH2:11][N:10]([CH2:15][CH2:16][CH2:17][Cl:5])[CH2:9]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 22822903HCID 22822903, compound

Product 1

HCID 13207837HCID 13207837, compound

Procedure

Thionyl chloride (300 g) was slowly added to 3-(3,5-cis-dimethylpiperazino)propanol dihydrochloride (200 g). The reaction was gently refluxed for an hour followed by removal of excess thionyl chloride by vacuum distillation. The resulting solid was washed with several portions of benzene then several portions of ether, m.p. 291°-292°.

Workup

  1. temperatureThe reaction was gently refluxed for an hour
  2. customfollowed by removal of excess thionyl chloride by vacuum distillation
  3. washThe resulting solid was washed with several portions of benzene

Sources & evidence

ORD record
ord-56c97d571e034ae4a2f50aac9b873653
Source dataset
uspto-grants-1983_04
Patent number
US04379160

Reaction notes

Loading…