Thionyl Chloride → HCID 23318285, compound

HRID 1701855Notes

Reaction equation

HRID 1701855 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:9][CH2:8][CH2:7][CH:6]2[CH2:10][CH2:11]O)[CH2:3][CH2:2]1.S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:15].[CH:1]1([CH2:4][N:5]2[CH2:9][CH2:8][CH2:7][CH:6]2[CH2:10][CH2:11][Cl:15])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 13647236HCID 13647236, compound

Product 1

HCID 23318285HCID 23318285, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
10 °C

Procedure

172 g of 1-cyclopropylmethyl 2-[2-hydroxyethyl]pyrrolidine (1.02 mole) and 510 ml of chloroform are introduced into a 3 liter balloon flask provided with a stirrer, a reflux condenser, a thermometer and a dropping funnel. The solution is cooled to 10° C. then 151.5 g of thionylchloride (1.02 mole+25%) is dropped in while keeping the temperature between 10° and 15° C.

Workup

  1. customprovided with a stirrer, a reflux condenser
  2. customthe temperature between 10° and 15° C.

Sources & evidence

ORD record
ord-35e76d955bb446bba94a1ffe7cdfd087
Source dataset
uspto-grants-1983_04
Patent number
US04379161

Reaction notes

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