Thiourea → HCID 13043951, compound
Reaction equation
[ClH:1].[Cl:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1.[NH2:14][C:15]([NH2:17])=[S:16]>C(O)C>[ClH:2].[ClH:1].[N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:12]=[CH:13][C:4]=1[CH2:3][S:16][C:15](=[NH:14])[NH2:17]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
A suspension, kept at 70° C., of 2-chloromethylquinoline hydrochloride (107 g) in ethanol (450 cc) is added dropwise and in the course of 15 minutes to a suspension of thiourea (45.5 g) in boiling ethanol (260 cc). The reaction mixture is stirred for 1 hour 30 minutes at the boil and then cooled to 20° C. The resulting crystals are filtered off, washed twice with ethanol (100 cc in total) and dried under reduced pressure (20 mm Hg; 2.7 kPa) at a temperature of about 20° C. 2-(Quinol-2-yl-methyl)-isothiourea dihydrochloride (141 g), melting at 250° C., is thus obtained.
Workup
- filtrationThe resulting crystals are filtered off
- washwashed twice with ethanol (100 cc in total)
- customdried under reduced pressure (20 mm Hg; 2.7 kPa) at a temperature of about 20° C
Sources & evidence
- ORD record
- ord-32dc93aa6c444c1798a64f043a28c10f
- Source dataset
- uspto-grants-1983_04
- Patent number
- US04379154
Reaction notes
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