Thiourea → HCID 13043951, compound

Participants

Reaction Conditions

Reaction Steps

A suspension, kept at 70° C., of 2-chloromethylquinoline hydrochloride (107 g) in ethanol (450 cc) is added dropwise and in the course of 15 minutes to a suspension of thiourea (45.5 g) in boiling ethanol (260 cc). The reaction mixture is stirred for 1 hour 30 minutes at the boil and then cooled to 20° C. The resulting crystals are filtered off, washed twice with ethanol (100 cc in total) and dried under reduced pressure (20 mm Hg; 2.7 kPa) at a temperature of about 20° C. 2-(Quinol-2-yl-methyl)-isothiourea dihydrochloride (141 g), melting at 250° C., is thus obtained.

Provenance & Evidence