Potassium Carbonate → HCID 135672583, compound

HRID 1701955Notes

Reaction equation

HRID 1701955 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:17][C:16](=[O:18])[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:27]([CH:29]1[O:31][CH2:30]1)Br>S1(CCCC1)(=O)=O>[O:31]1[CH:29]([CH3:27])[CH:30]1[O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[NH:17][C:16](=[O:18])[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 18430EpibromohydrinHCID 135672582HCID 135672582, compound

Product 1

HCID 135672583HCID 135672583, compound

Reagents, catalysts & solvents 1

HCID 31347SulfolaneSolvent

Procedure

4.5 gm (16.7 mmols) of 2-(4-hydroxy-phenyl)-6-methoxy-3,4-dihydro-quinazolin-4-one were dissolved in 50 ml of sulfolane, and the solution was mixed, while stirring, with 2.55 gm (16.7 mmols+10%) of potassium carbonate. After a clear solution was formed, 4.5 ml of epibromohydrin were added, and the mixture was stirred at room temperature until the reaction was complete. The reaction mixture was poured into ice water, and the resulting crystalline precipitate was suction-filtered off, washed well with water and dried.

Workup

  1. additionthe solution was mixed
  2. customAfter a clear solution was formed
  3. filtrationthe resulting crystalline precipitate was suction-filtered off
  4. washwashed well with water
  5. customdried

Sources & evidence

ORD record
ord-a79772914c1848b09ed999b3b5506431
Source dataset
uspto-grants-1983_04
Patent number
US04379788

Reaction notes

Loading…