Pyrrolidine → HCID 13610541, compound

HRID 1701976Notes

Reaction equation

HRID 1701976 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH:9]=O)[CH2:3][CH2:2]1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>O1CCOCC1.[Ni]>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 31268PyrrolidineHCID 111054823-Morpholinopropanal

Product 1

HCID 13610541HCID 13610541, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 312751,4-DioxaneSolvent

Procedure

143 g (1 mol) of 3-morpholinopropionaldehyde in 143 g of dioxane are pumped into 71 g (1 mol) of pyrrolidine and 40 g of Raney nickel at 120° C. and hydrogenated at 160 bar. The reaction mixture is suction filtered, concentrated by evaporation and distilled. B.p. 0.1 : 82° C., purity according to gas chromatogram: 94.5%. Yield: 51 g; molar mass found: 196 v. the molecular weight calculated for C11H22N2O: 198.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated by evaporation
  3. distillationdistilled
  4. custom82° C., purity

Sources & evidence

ORD record
ord-1077c204ed21410fae60203e25328b6c
Source dataset
uspto-grants-1983_04
Patent number
US04379861

Reaction notes

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