Potassium Hydroxide → HCID 53995472, compound

Participants

Reaction Steps

To a solution of 4.44 g of 2-bromo-1-(2,4-dichlorophenyl)-4,4-dimethyl-1-phenylsulfonylpentan-3-one in 50 ml of tetrahydrofuran, a solution of 0.56 g of potassium hydroxide in 30 ml of water was added dropwise and vigorously stirred for 3 hours. The reaction mixture was combined with 100 ml of ice water, and extracted with 100 ml of chloroform. The organic solvent layer was washed twice with water, dried over anhydrous sodium sulfate, and evaporated under reduced pressure to give 3.61 g of 1-(2,4-dichlorophenyl)-4,4-dimethyl-1-phenylsulfonyl-1-penten-3-one.

Provenance & Evidence