Potassium Hydroxide → HCID 53995472, compound

HRID 1702003Notes

Reaction equation

HRID 1702003 reaction equation
Br[CH:2]([C:21](=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23])[CH:3]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[Cl:20])[S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5].[OH-].[K+]>O1CCCC1.O>[Cl:20][C:14]1[CH:15]=[C:16]([Cl:19])[CH:17]=[CH:18][C:13]=1[C:3]([S:4]([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)(=[O:6])=[O:5])=[CH:2][C:21](=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 13048613HCID 13048613, compound

Product 1

HCID 53995472HCID 53995472, compoundYield 97.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 4.44 g of 2-bromo-1-(2,4-dichlorophenyl)-4,4-dimethyl-1-phenylsulfonylpentan-3-one in 50 ml of tetrahydrofuran, a solution of 0.56 g of potassium hydroxide in 30 ml of water was added dropwise and vigorously stirred for 3 hours. The reaction mixture was combined with 100 ml of ice water, and extracted with 100 ml of chloroform. The organic solvent layer was washed twice with water, dried over anhydrous sodium sulfate, and evaporated under reduced pressure to give 3.61 g of 1-(2,4-dichlorophenyl)-4,4-dimethyl-1-phenylsulfonyl-1-penten-3-one.

Workup

  1. extractionextracted with 100 ml of chloroform
  2. washThe organic solvent layer was washed twice with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-de69706c407f46a88219672c46a24043
Source dataset
uspto-grants-1983_04
Patent number
US04379921

Reaction notes

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