反应详情

A mixture of 2.1 g of 1'-methylspiro[indoline-3,4'-piperidine] (Example 1b), 3 g of 50% sodium hydride and 12 ml of fluorobenzene in 18 ml of dimethyl sulfoxide is stirred at 65°-70° C. for 45 hours. The well stirred mixture is poured into water and extracted thrice with ether. The combined ether extracts are dried briefly before forming, the hydrochloride salt. The salt is collected, basified and then extracted into ether, giving a yellowish oil which is crystallized from hexane, producing off-white crystals, mp 90°-92° C. of 1'-methyl-1-phenylspiro[indoline-3,4'-piperidine].

1. stirringThe well stirred mixture
2. extractionextracted thrice with ether
3. dry with materialThe combined ether extracts are dried briefly
4. custombefore forming
5. customThe salt is collected
6. extractionextracted into ether
7. customgiving a yellowish oil which
8. customis crystallized from hexane