Hydrochloric Acid → HCID 20442643, compound
Reaction equation
C([N:3]1[CH2:8][CH2:7][C:6]2([C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:9]2)[CH2:5][CH2:4]1)#N.Cl>>[C:17]1([N:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:6]3([CH2:5][CH2:4][NH:3][CH2:8][CH2:7]3)[CH2:9]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1Participants
3
Procedure
A mixture of 1'-cyano-1-phenylspiro[indoline-3,4'-piperidine] (Example 8), is treated with 3 N hydrochloric acid under reflux to provide 1-phenylspiro[indoline-3,4'-piperidine].
Workup
- temperatureunder reflux
Sources & evidence
- ORD record
- ord-8862598476414c4c97bfb17fb5e56463
- Source dataset
- uspto-grants-1983_04
- Patent number
- US04379932
Reaction notes
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