Potassium Carbonate → 2-(2-Chlorophenyl)bicyclopropyl
Reaction equation
C(=O)([O-])[O-].[K+].[K+].[Cl:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]1NN=[C:16]([CH:19]2[CH2:21][CH2:20]2)[CH2:15]1>C(O)CO>[Cl:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]1[CH2:15][CH:16]1[CH:19]1[CH2:21][CH2:20]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
To a solution of 50 g (0.36 mol) of potassium carbonate in 600 g of ethylene glycol there are added at 190° C., in the course of 2 hours, 201.5 g of 5-(2-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole, prepared as described under A2. Stirring is then carried out for 2 hours at 190° C. The end of the reaction is indicated by cessation of the evolution of gas. The reaction mixture is then cooled to 100° C., whereupon phase separation occurs and the upper, product phase is separated off. 158 g of 2-(2-chlorophenyl)bicyclopropyl are obtained as crude product, which may be further purified, for example by distillation.
Workup
- customprepared
- customthe upper, product phase is separated off
Sources & evidence
- ORD record
- ord-b4ca4be6029f49a1af47e8574d8f9927
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07737301B2
Reaction notes
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