反应详情

In DMF was dissolved 935 mg of the above ester, and to the resulting solution were added 0.5 g of 10% palladium-carbon (Pd-C) and 0.98 ml of a 2 N hydrochloric acid-dioxane solution, after which hydrogen gas was passed through the resulting mixture with ice-cooling and with stirring for 4 hrs. After the reaction, the Pd-C was removed by filtration, and 300 ml of anhydrous diethyl ether was added dropwise to the filtrate, upon which a powder was precipitated. The powder was collected by filtration to obtain 450 mg (yield 78%) of L-phenylalanyl-L-arginine 1-naphthyl ester dihydrochloride, m.p. 215° C. (decomp.).

1. temperaturecooling
2. customAfter the reaction
3. customthe Pd-C was removed by filtration, and 300 ml of anhydrous diethyl ether
4. additionwas added dropwise to the filtrate, upon which a powder
5. customwas precipitated
6. filtrationThe powder was collected by filtration