反应详情

In 10 ml of DMF was dissolved 1.07 g of the above ester, after which 0.5 g of 10% Pd-C and 1.65 ml of 2 N hydrochloric acid-dioxane solution were added thereto. The mixture was stirred with ice-cooling for 3 hrs while passing hydrogen gas therethrough. After the reaction, the reaction mixture was filtered to remove the Pd-C, and 500 ml of anhydrous diethyl ether was added to the filtrate. The white powder thus precipitated was collected and vacuum-dried over P2O5 at 110° C. for 3 hrs to obtain 700 mg (yield 92%) of benzoyl-L-phenylalanyl-L-arginine 1-naphthyl ester hydrochloride, m.p. 112° C.-(decomp.).

1. temperaturecooling for 3 hrs
2. customAfter the reaction
3. filtrationthe reaction mixture was filtered
4. customto remove the Pd-C, and 500 ml of anhydrous diethyl ether
5. additionwas added to the filtrate
6. customThe white powder thus precipitated
7. customwas collected
8. dry with materialvacuum-dried over P2O5 at 110° C. for 3 hrs