Dimethylformamide dimethyl acetal → HCID 54559550, compound

HRID 1702161Notes

Reaction equation

HRID 1702161 reaction equation
[CH3:1][C:2]([CH3:12])([CH3:11])[C:3](=[O:10])[CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1.CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>>[CH3:1][C:2]([CH3:12])([CH3:11])[C:3](=[O:10])[C:4]([N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1)=[CH:15][N:16]([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 127694531-(1H-Imidazol-1-yl)-3,3-dimethylbutan-2-one

Product 1

HCID 54559550HCID 54559550, compoundYield 90.5%

Procedure

41.6 g (0.25 mol) of 3,3-dimethyl-1-(imidazol-1-yl)-butan-2-one and 35.7 g (0.3 mol) of dimethylformamide dimethyl acetal were heated under reflux for 5 hours. The excess acetal was then distilled off. The oil which remained crystallized on cooling. 50 g (90.5% of theory) of 4,4-dimethyl-1-dimethylamino-2-(imidazol-1-yl)-pent-1-en-3-one of melting point 45°-50° C. were obtained. ##STR16##

Workup

  1. temperatureunder reflux for 5 hours
  2. distillationThe excess acetal was then distilled off
  3. customThe oil which remained crystallized
  4. temperatureon cooling

Sources & evidence

ORD record
ord-ced79527e7d44eb0b236eafe45e467d7
Source dataset
uspto-grants-1983_04
Patent number
US04380628

Reaction notes

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