Methylamine → HCID 178482522, compound

HRID 1702238Notes

Reaction equation

HRID 1702238 reaction equation
[OH:1][CH2:2][C:3]1[NH:7][CH:6]=[N:5][C:4]=1[CH2:8][S:9][CH2:10][CH2:11][NH2:12].COC1C(OC)=NS(=O)(=O)N=1.OCC1NC=NC=1CSC[CH2:34][NH:35][C:36]1[C:40](OC)=[N:39][S:38](=[O:44])(=[O:43])[N:37]=1.CN>>[OH:1][CH2:2][C:3]1[NH:7][CH:6]=[N:5][C:4]=1[CH2:8][S:9][CH2:10][CH2:11][NH:12][C:40]1[C:36]([NH:35][CH3:34])=[N:37][S:38](=[O:44])(=[O:43])[N:39]=1

Participants

5

Reactant 4

HCID 6329MethylamineHCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxideHCID 178494336HCID 178494336, compoundHCID 178511472HCID 178511472, compound

Product 1

HCID 178482522HCID 178482522, compound

Procedure

2-[(5-Hydroxymethyl-1H-imidazol-4-yl)methylthio]ethylamine [prepared according to the procedure described in Belgian Pat. No. 843,840] is reacted with 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide and the resultant 3-{2-[(5-hydroxymethyl-1H-imidazol-4-yl)methylthio]ethylamino}-4-methoxy-1,2,5-thiadiazole 1,1-dioxide is treated with excess methylamine according to the general procedure described in Example 2, and the title compound is thereby produced.

Sources & evidence

ORD record
ord-3c4d5d5a857e422cb2712a233cc0df90
Source dataset
uspto-grants-1983_04
Patent number
US04380638

Reaction notes

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