Methylamine → HCID 178482514, compound

HRID 1702247Notes

Reaction equation

HRID 1702247 reaction equation
COC1C(OC)=NS(=O)(=O)N=1.[CH3:12][N:13]([CH2:15][C:16]1[O:20][C:19]([CH2:21][S:22][CH2:23][CH2:24][NH2:25])=[CH:18][C:17]=1[CH3:26])[CH3:14].CN(CC1OC(CSC[CH2:39][NH:40][C:41]2[C:45](OC)=[N:44][S:43](=[O:49])(=[O:48])[N:42]=2)=CC=1C)C.CN>CO>[CH3:14][N:13]([CH2:15][C:16]1[O:20][C:19]([CH2:21][S:22][CH2:23][CH2:24][NH:25][C:45]2[C:41]([NH:40][CH3:39])=[N:42][S:43](=[O:49])(=[O:48])[N:44]=2)=[CH:18][C:17]=1[CH3:26])[CH3:12]

Participants

6

Reactant 4

HCID 6329MethylamineHCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxideHCID 131251172-[(5-Dimethylaminomethyl-4-methyl-2-furyl)methylthio]ethylamineHCID 178494328HCID 178494328, compound

Product 1

HCID 178482514HCID 178482514, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

When a methanol suspension of 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide is reacted with an equimolar amount of 2-[(5-dimethylaminomethyl-4-methyl-2-furyl)methylthio]ethylamine [prepared in Step C] and the resultant 3-{2-[(5-dimethylaminomethyl-4-methyl-2-furyl)methylthio]ethylamino}-4-methoxy-1,2,5-thiadiazole 1,1-dioxide is treated with an excess of methylamine, the title compound is produced.

Sources & evidence

ORD record
ord-b981568f13604e0592e590f34de9043a
Source dataset
uspto-grants-1983_04
Patent number
US04380638

Reaction notes

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