Methylamine → HCID 178482518, compound

HRID 1702269Notes

Reaction equation

HRID 1702269 reaction equation
COC1C(OC)=NS(=O)(=O)N=1.CN.CO[C:16]1[C:20]([NH:21][CH3:22])=[N:19][S:18](=[O:24])(=[O:23])[N:17]=1.[NH:25]([C:29]1[S:30][CH:31]=[C:32]([CH2:34][S:35][CH2:36][CH2:37][NH2:38])[N:33]=1)[C:26]([NH2:28])=[NH:27]>>[NH:25]([C:29]1[S:30][CH:31]=[C:32]([CH2:34][S:35][CH2:36][CH2:37][NH:38][C:16]2[C:20]([NH:21][CH3:22])=[N:19][S:18](=[O:24])(=[O:23])[N:17]=2)[N:33]=1)[C:26]([NH2:28])=[NH:27]

Participants

5

Reactant 4

HCID 6329MethylamineHCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxideHCID 178482530HCID 178482530, compoundHCID 1785127232-[4-(2-Aminoethylsulfanylmethyl)-1,3-thiazol-2-yl]guanidine

Product 1

HCID 178482518HCID 178482518, compound

Procedure

Reaction of a methanolic suspension of 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide with one equivalent of methylamine and treatment of the resultant 3-methoxy-4-methylamino-1,2,5-thiadiazole 1,1-dioxide with one equivalent of 2-[(2-guanidinothiazol-4-yl)methylthio]ethylamine yields the title compound, which is identical to the product obtained in Example 31.

Sources & evidence

ORD record
ord-d1ae2088942f4022bac987e095c67565
Source dataset
uspto-grants-1983_04
Patent number
US04380638

Reaction notes

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