Hydrazine hydrate (1:1) → HCID 178512516, compound

HRID 1702327Notes

Reaction equation

HRID 1702327 reaction equation
Cl.[NH:2]([C:6]1[CH:7]=[C:8]([CH:24]=[CH:25][CH:26]=1)[O:9][CH2:10][CH2:11][CH2:12][N:13]1C(=O)C2=CC=CC=C2C1=O)[C:3]([NH2:5])=[NH:4].O.NN>C(O)C>[NH:2]([C:6]1[CH:7]=[C:8]([CH:24]=[CH:25][CH:26]=1)[O:9][CH2:10][CH2:11][CH2:12][NH2:13])[C:3]([NH2:5])=[NH:4]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178479378HCID 178479378, compound

Product 1

HCID 178512516HCID 178512516, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a partial suspension of N-[3-(3-guanidinophenoxy)propyl]phthalimide hydrochloride (1.0 g; 2.95 mmoles) in 10 ml of 95% aqueous ethanol was added 0.27 ml of hydrazine hydrate. The mixture was stirred at ambient temperature for 17 hours and evaporated under reduced pressure to give the title compound. The product was used without further purification in Step E.

Workup

  1. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-d7ef5e0a02674461b833369741f8af28
Source dataset
uspto-grants-1983_04
Patent number
US04380638

Reaction notes

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