(2-((Dimethylamino)methyl)thiazol-4-yl)methanol → HCID 178482517, compound

HRID 1702369Notes

Reaction equation

HRID 1702369 reaction equation
[CH3:1][NH:2][C:3]1[C:7](CCS)=[N:6][S:5](=[O:12])(=[O:11])[N:4]=1.[CH3:13][N:14]([CH2:16][C:17]1[S:18][CH:19]=[C:20]([CH2:22]O)[N:21]=1)[CH3:15]>Cl>[CH3:13][N:14]([CH2:16][C:17]1[S:18][CH:19]=[C:20]([CH2:22][S:18][CH2:17][CH2:16][NH:14][C:7]2[C:3]([NH:2][CH3:1])=[N:4][S:5](=[O:11])(=[O:12])[N:6]=2)[N:21]=1)[CH3:15]

Participants

4

Reactant 2

HCID 1838020(2-((Dimethylamino)methyl)thiazol-4-yl)methanolHCID 178482509HCID 178482509, compound

Product 1

HCID 178482517HCID 178482517, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Reaction of 3-methylamino-4-(2-mercaptoethyl)-1,2,5-thiadiazole 1,1-dioxide [prepared in Example 25, Step A] with about one equivalent of 2-dimethylaminomethyl-4-hydroxymethylthiazole [prepared in Example 34, Step D] in concentrated hydrochloric acid, and then made basic and worked up, produces the title compound which is identical to the product prepared in Example 33.

Sources & evidence

ORD record
ord-fd78368824d3405087a8b38afd6a4ed9
Source dataset
uspto-grants-1983_04
Patent number
US04380639

Reaction notes

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