N-(2-Chloro-3-pyridinyl)-4-(methylamino)-N,1,3-trimethyl-1H-pyrazole-5-carboxamide → 1,4,9,10-Tetrahydro-1,3,4,9-tetramethyl-pyrazolo[4,3-e]pyrido[3,2-b][1,4]diazepin-10-one

Participants

Reaction Steps

An amount of 5.9 gm of N-(2-chloro-3-pyridinyl)-N-methyl-1,3-dimethyl-4-methylamino-1H-pyrazole-5-carboxamide was stirred in 6 ml of 1,2,4-trichlorobenzene for 5 hours at 180° C. After cooling, the crystal slurry was subjected to suction filtration, washed with cyclohexane, and recrystallized from aqueous ethanol.

Provenance & Evidence