N-(2-Chloro-3-pyridinyl)-4-(methylamino)-N,1,3-trimethyl-1H-pyrazole-5-carboxamide → 1,4,9,10-Tetrahydro-1,3,4,9-tetramethyl-pyrazolo[4,3-e]pyrido[3,2-b][1,4]diazepin-10-one

HRID 1702440Notes

Reaction equation

HRID 1702440 reaction equation
Cl[C:2]1[C:7]([N:8]([CH3:20])[C:9]([C:11]2[N:15]([CH3:16])[N:14]=[C:13]([CH3:17])[C:12]=2[NH:18][CH3:19])=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1>ClC1C=CC(Cl)=CC=1Cl>[CH3:16][N:15]1[C:11]2[C:9](=[O:10])[N:8]([CH3:20])[C:7]3[CH:6]=[CH:5][CH:4]=[N:3][C:2]=3[N:18]([CH3:19])[C:12]=2[C:13]([CH3:17])=[N:14]1

Participants

3

Reactant 1

HCID 20503813N-(2-Chloro-3-pyridinyl)-4-(methylamino)-N,1,3-trimethyl-1H-pyrazole-5-carboxamide

Product 1

HCID 205038201,4,9,10-Tetrahydro-1,3,4,9-tetramethyl-pyrazolo[4,3-e]pyrido[3,2-b][1,4]diazepin-10-one

Reagents, catalysts & solvents 1

HCID 131,2,4-TrichlorobenzeneSolvent

Procedure

An amount of 5.9 gm of N-(2-chloro-3-pyridinyl)-N-methyl-1,3-dimethyl-4-methylamino-1H-pyrazole-5-carboxamide was stirred in 6 ml of 1,2,4-trichlorobenzene for 5 hours at 180° C. After cooling, the crystal slurry was subjected to suction filtration, washed with cyclohexane, and recrystallized from aqueous ethanol.

Workup

  1. temperatureAfter cooling
  2. filtrationthe crystal slurry was subjected to suction filtration
  3. washwashed with cyclohexane
  4. customrecrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-93fa853a05ba40b7b378cc9f29414012
Source dataset
uspto-grants-1983_04
Patent number
US04381303

Reaction notes

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