Sodium Carbonate → 9,10-dihydro-4-(pyrrolidinoacetyl)-4H-thieno[3,4-b][1,5]benzodiazepin-10-one

Participants

Reaction Steps

1.9 g of 4-chloroacetyl-9,10-dihydro-4H-thieno[3,4-b][1,5]benzodiazepin-10-one, 0.55 g of pyrrolidine, 0.85 g of ground sodium carbonate and 15 ml of absolute ethanol are heated at the boil for 2 hours, and the resulting hot solution is filtered and concentrated in vacuo. The obtained residue is dissolved in methylene chloride; the organic solution is washed at pH 7 with water and then concentrated; 1.4 g of 9,10-dihydro-4-(pyrrolidinoacetyl)-4H-thieno[3,4-b][1,5]benzodiazepin-10-one are thus obtained.

Provenance & Evidence